Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/45001
Title: Fructose-1,6-diphosphate: Potential protection in cyclosporine-induced renal impairment
Authors: Cardoso, Lucio Ronaldo
Santos, Oscar Fernando Pavão dos [UNIFESP]
Boim, Mirian Aparecida [UNIFESP]
Barros, Elvino José Guardião
Ajzen, Horacio [UNIFESP]
Schor, Nestor [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
FED UNIV RIO DE JANEIRO
UNIV FED RIO GRANDE SUL
Keywords: nephrotoxicity
fructose-1,6-diphosphate
cyclosporine
acute renal failure
glomeruli
Issue Date: 1-Jan-1996
Publisher: Karger
Citation: Nephron. Basel: Karger, v. 72, n. 1, p. 67-71, 1996.
Abstract: There is evidence that fructose-1,6-diphosphate (FDP) provides protection from hepatic and cardiac toxic-induced damage and ischemic renal insult. To determine ifFDP also protects against cyclosporine (CsA)-induced nephrotoxicity, two groups of adult male Wistar rats were studied for whole kidney clearance rates. After two initial control periods, group 1 received only CsA (CsA, n = 8). Group 2 received FDP 350 mg/kg, followed by CsA 50 mg/kg (FDP-CsA, n = 6). In both groups, after a 30-min equilibration period, two additional clearance rates were measured (Post1 and Post2). A significant reduction in clearance rates was observed after drug infusion in both groups (approximately 58 and 64% in CsA and FDP-CsA groups, respectively, p < 0.05) with a recovery to control values in the Post2 period in the FDP-CsA group. These data suggest a protective effect of FDP on CsA-induced renal impairment.
URI: http://repositorio.unifesp.br/11600/45001
ISSN: 0028-2766
Other Identifiers: http://dx.doi.org/10.1159/000188808
Appears in Collections:Artigo

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