Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/44970
Title: Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella
Authors: Grecco, Simone dos Santos [UNIFESP]
Felix, Maria Julia Pereira [UNIFESP]
Lago, Joao Henrique Ghilardi [UNIFESP]
Pinto, Erika Gracielle
Tempone, André Gustavo
Romoff, Paulete
Ferreira, Marcelo José Pena
Sartorelli, Patricia [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Adolfo Lutz Inst
Universidade de São Paulo (USP)
Univ Presbiteriana Mackenzie
Keywords: Baccharis uncinella
Asteraceae
Antitrypanosomal
Flavanones
Chlorogenic acids
Cinnamic acid derivatives
Issue Date: 1-Feb-2014
Publisher: Natural Products Inc
Citation: Natural Product Communications. Westerville: Natural Products Inc, v. 9, n. 2, p. 171-173, 2014.
Abstract: Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mu g/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 mu g/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mu g/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 mu g/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella.
URI: http://repositorio.unifesp.br/11600/44970
ISSN: 1934-578X
Appears in Collections:Artigo

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