Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/44921
Title: Methionyl aminopeptidase from rat liver: distribution of the membrane-bound subcellular enzyme
Authors: Termignoni, Carlos
Freitas Junior, Jose Olavo de [UNIFESP]
Guimarães, Jorge Almeida
Universidade Federal do Rio de Janeiro (UFRJ)
UNIV FED RIO GRANDE SUL
Universidade Federal de São Paulo (UNIFESP)
Keywords: METHIONYL AMINOPEPTIDASE
N-TERMINAL METHIONINE
AMINOPEPTIDASE
ARYLAMIDASE
RAT LIVER
Issue Date: 10-Apr-1991
Publisher: Kluwer Academic Publ
Citation: Molecular And Cellular Biochemistry. Dordrecht: Kluwer Academic Publ, v. 102, n. 2, p. 101-113, 1991.
Abstract: The selective distribution of methionyl aminopeptidase (MAP) among rat liver mitochondria (heavy and light) and microsomes is reported. Several properties of MAP from the three subcellular fractions showed that the enzyme is a typical aminopeptidase able to remove N-terminal methionine from oligopeptides and methionyl-2-naphthylamide but not from Met-Ala-Ser. MAP is a membrane-bound enzyme sensitive to SH-group oxidants and inhibitable by L-methionine but not by usual arylaminopeptidase inhibitors. It is suggested that, MAP may play an important role during protein synthesis in rat liver.
URI: http://repositorio.unifesp.br/11600/44921
ISSN: 0300-8177
Other Identifiers: http://dx.doi.org/10.1007/BF00234568
Appears in Collections:Artigo

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