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|Title:||Further insights into B-1 cell biology|
|Authors:||Mariano, Mario [UNIFESP]|
Universidade Federal de São Paulo (UNIFESP)
|Publisher:||Medicina (buenos Aires)|
|Citation:||Medicina-buenos Aires. Buenos Aires: Medicina (buenos Aires), v. 67, n. Supl 2, p. 48-50, 2007.|
|Abstract:||The term B-1 cell was originally proposed to describe a subtype of B lymphocytes, which differs from 8 conventional cells by anatomical localization, developmental origin, surface markers expression, antibody repertoire and growth properties. B-1 cells express high levels of surface IgM, low levels of B220 (CD45R) and IgD, but not CD23, whereas conventional B-2 cells express high levels of B220 and IgD, CD23 and low levels of IgM. Besides, typical B-1 cells residing in peritoneal cavity also express low levels of Mac-1 (CD11b). Further, B-1 cells are sub classified in B-1a cells, which express CD5, and their phenotypic CD5(-) twins, B-1b cells. Our laboratory has demonstrated that B-1b cells proliferate in cultures of adherent mouse peritoneal cells and differentiate into a mononuclear phagocyte, provisionally named lymphophage. Yet, that these cells migrate from the peritoneal cavity to a non specific inflammatory lesion. From these observations the origin, differentiation and function of these cells in normal and pathological conditions have been intensively investigated in our laboratory. The morphology of B-1 cells, its participation in giant cell formation and granuloma development in vitro, and facilitation of murine melanoma growth will be presented and discussed.|
|Appears in Collections:||Artigo|
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