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Title: Quantitation of the soluble E-receptor of human T lymphocytes by rocket electrophoresis in the serum of patients with lepromatous and tuberculoid leprosy
Authors: Longo-Maugéri, Ieda Maria [UNIFESP]
Moura, N. C. [UNIFESP]
Opromolla, Diltor Vladimir Araujo [UNIFESP]
Mendes, Nelson Figueiredo [UNIFESP]
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jan-1991
Publisher: Medicina (buenos Aires)
Citation: Medicina-buenos Aires. Buenos Aires: Medicina (buenos Aires), v. 51, n. 2, p. 133-136, 1991.
Abstract: Human T lymphocytes carry a membrane receptor for sheep erythrocytes (E) which is responsible for the well-known phenomenon of E-rosette formation. This receptor has been related to CD2 molecules; it is present in a soluble form (Rs) in normal serum and may play an immunoregulatory role. In this study we quantitated soluble E-receptor in serum samples of 43 normal controls, 32 patients with tuberculoid leprosy and 53 with lepromatous leprosy, using rocket electrophoresis and an anti E receptor serum (anti-Rs) obtained from an adult sheep immunized with autologous E treated with Rs. In the 3 groups studied, the rocket means were respectively 5.0, 7.5 and 10.9 mm (p < 0.001). We found abnormally high levels of Rs in the serum of various diseases associated with a depression of cell-mediated immunity. The increase of Rs levels in the serum may be one of the mechanisms responsible for the depression of cellular immunity in leprosy.
ISSN: 0025-7680
Appears in Collections:Artigo

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