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Title: Sepsis: a roadmap for future research
Authors: Cohen, Jonathan
Vincent, Jean-Louis
Adhikari, Neill K. J.
Machado, Flávia Ribeiro [UNIFESP]
Angus, Derek C.
Calandra, Thierry
Jaton, Katia
Giulieri, Stefano
Delaloye, Julie
Opal, Steven
Tracey, Kevin
van der Poll, Tom
Pelfrene, Eric
Brighton & Sussex Med Sch
Univ Brussels
Sunnybrook Hlth Sci Ctr
Univ Toronto
Universidade Federal de São Paulo (UNIFESP)
Univ Pittsburgh
CHU Vaudois
Univ Lausanne
Brown Univ
Feinstein Inst Med Res
Univ Amsterdam
European Med Agcy
Issue Date: 1-May-2015
Publisher: Elsevier B.V.
Citation: Lancet Infectious Diseases. Oxford: Elsevier Sci Ltd, v. 15, n. 5, p. 581-614, 2015.
Abstract: Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, induding administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments. Existing models of clinical research seem increasingly unlikely to produce new therapies that will result in a step change in clinical outcomes. In this Commission, we set out our understanding of the clinical epidemiology and management of sepsis and then ask how the present approaches might be challenged to develop a new roadmap for future research.
ISSN: 1473-3099
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