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Title: Apoptosis of leukocytes: Basic concepts and implications in uremia
Authors: Jaber, Bertrand L. [UNIFESP]
Cendoroglo Neto, Miguel [UNIFESP]
Balakrishnan, Vaidyanathapuram S.
Perianayagam, Mary C.
King, Andrew J.
Pereira, Brian JG
Univ Fed Ceara
Hosp Clin Montevideo
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal Fluminense (UFF)
Keywords: cell death
Issue Date: 1-Feb-2001
Publisher: Blackwell Science Inc
Citation: Kidney International. Malden: Blackwell Science Inc, v. 59, n. supl 78, p. S197-S205, 2001.
Abstract: Circulating blood leukocytes have short life expectancies and end their lives by committing programmed cell death or apoptosis. Apoptosis is an active form of cell death that is initiated by a number of stimuli and is intricately regulated. Apoptosis in both excessive and reduced amounts has pathological implications. Evidence suggests that apoptosis may play a role in the pathophysiology of immune dysfunction in uremia. Indeed, accelerated programmed cell death has been observed in lymphocytes, monocytes, and polymorphonuclear leukocytes among patients with chronic renal failure. This may be due in part to the retention of uremic toxins. The aim of this article is to review the evidence for accelerated leukocyte apoptosis, key regulatory apoptotic pathways, and the possible role of this highly organized process in the pathogenesis of immune dysfunction in uremia.
ISSN: 0085-2538
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Appears in Collections:Artigo

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