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Title: Laparoscopic evaluation of abdominal adhesions with different prosthetic meshes in rabbits
Authors: Marcondes, Wagner [UNIFESP]
Herbella, Fernando Augusto Mardiros [UNIFESP]
Matone, Jacques [UNIFESP]
Odashiro, Alexandre Nakao [UNIFESP]
Goldenberg, Alberto [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: adhesions
hernia repair
prosthetic materials
Issue Date: 1-Jan-2008
Publisher: Soc Laparoendoscopic Surgeons
Citation: Jsls-journal Of The Society Of Laparoendoscopic Surgeons. Miami: Soc Laparoendoscopic Surgeons, v. 12, n. 1, p. 58-61, 2008.
Abstract: Background: The use of prosthetic materials to reinforce the abdominal wall is associated with a low index of recurrence; however, intraperitoneal placement of a foreign body may lead to adhesions. The present investigation was designed to determine adhesion formation with commercially available meshes implanted laparoscopically in rabbits.Methods: Three different meshes were implanted laparoscopically in 24 rabbits: polypropylene (mesh A), polypropylene and sodium hyaluronate-carboxymethylecellulose (mesh B), and polypropylene and expanded polytetra-fluoroethylene (mesh C), Sites of implantation for each mesh (the left lower quadrant, right lower quadrant, and lower midline) were randomly determined so that every rabbit had all 3 meshes implanted. All animals underwent diagnostic laparoscopy after 28 days to grade adhesions and histological analysis of inflammation.Results: Adhesions were noticed in 46 of the 72 meshes implanted (64%). The number of adhesions was higher for mesh C (87.5%) compared with meshes A (62.5%) and B (41.6%). The severity of adhesions was also higher for mesh C (grade I in 14, II in 6, and III in 1) compared with mesh A (grade I in 10, II in 4, and III in 1 case) and B (all of them grade II). Histological inflammatory reaction was classified as mild in 23 cases of mesh A, 15 of mesh B, and 23 of mesh C. A moderate reaction was found in 1 case of mesh A, 4 cases of mesh B, and 1 case of mesh C. Severe reaction was induced in 5 cases of mesh B. Mesh B induced a higher inflammatory reaction compared with the other meshes.
ISSN: 1086-8089
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