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Title: APOA4 Polymorphism as a Risk Factor for Unfavorable Lipid Serum Profile and Depression: A Cross-Sectional Study
Authors: Ota, Vanessa Kiyomi [UNIFESP]
Chen, Elizabeth Suchi [UNIFESP]
Ejchel, Tatiana Flank [UNIFESP]
Furuya, Tatiane Katsue [UNIFESP]
Mazzotti, Diego Robles [UNIFESP]
Cendoroglo, Maysa Seabra [UNIFESP]
Ramos, Luiz Roberto [UNIFESP]
Araujo, Lara Quirino [UNIFESP]
Burbano, Rommel Rodriguez [UNIFESP]
Cardoso Smith, Marilia de Arruda [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: APOC-III
elderly population
Issue Date: 1-Aug-2011
Publisher: Lippincott Williams & Wilkins
Citation: Journal Of Investigative Medicine. Philadelphia: Lippincott Williams & Wilkins, v. 59, n. 6, p. 966-970, 2011.
Abstract: Introduction: APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. Here, we aimed to investigate associations of APOC3 (3238C9G, j482C9T, 1100C9T) and APOA4 (Gln360His, Thr347Ser) polymorphisms in 382 individuals from a cohort of a Longitudinal Brazilian Elderly Study with major agerelated morbidities and with lipid and protein serum levels.Materials and Methods: The whole sample was genotyped by polymerase chain reactionYrestriction fragment length polymorphism. Descriptive statistics, logistic regression analysis, Student t test, deviation from Hardy-Weinberg, Bonferroni correction for multiple testing, and haplotype analyses were performed.Results: Although APOC3 1100T allele carriers presented lower triglyceride and very low density lipoprotein levels than non-T carriers, these associations disappeared after Bonferroni correction (P > 0.05). Moreover, APOA4 360His allele was associated with depression (P = 0.03), increased triglyceride (P = 0.035) and very low density lipoprotein (P = 0.035) levels, and reduced HDL levels (P = 0.0005). Haplotype analyses found an association between His/C/C haplotype (Gln360His/-482C>T/1100C>T) with depression, but this result was due to Gln360His polymorphism.Conclusions: Our data suggest that 360His allele might be a risk factor for depression and unfavorable lipid profile and depression for elderly people in the Brazilian population.
ISSN: 1081-5589
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