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Title: Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment
Authors: Belnoue, Elodie
Costa, Fabio TM
Frankenberg, Tobias
Vigario, Ana Margarida
Voza, Tatiana
Leroy, Nicolas
Rodrigues, Mauricio Martins [UNIFESP]
Landau, Irène
Snounou, Georges
Renia, Laurent
Univ Paris 05
Universidade Estadual de Campinas (UNICAMP)
Museum Natl Hist Nat
Universidade Federal de São Paulo (UNIFESP)
Inst Pasteur
Issue Date: 15-Feb-2004
Publisher: Amer Assoc Immunologists
Citation: Journal Of Immunology. Bethesda: Amer Assoc Immunologists, v. 172, n. 4, p. 2487-2495, 2004.
Abstract: In this study we present the first systematic analysis of the immunity induced by normal Plasmodium yoelii sporozoites in mice. Immunization With sporozoites, which was conducted under chloroquine treatment to minimize the influence of blood stage parasites, induced a strong protection against a subsequent sporozoite and, to a lesser extent, against infected RBC challenges. The protection induced by this immunization protocol proved to be very effective. Induction of this protective immunity depended on the presence of liver stage parasites, as primaquine treatment concurrent with sporozoite immunization abrogated protection. Protection was not found to be mediated by the Abs elicited against pre-erythrocytic and blood stage parasites, as demonstrated by inhibition assays of sporozoite penetration or development in vitro and in vivo assays of sporozoite infectivity or blood stage parasite development. CD4(+) and CD8(+) T cells were, however, responsible for the protection through the induction of IFN-gamma and NO. The Journal of Immunology, 2004, 172: 2487-2495.
ISSN: 0022-1767
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