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Title: Influence of temporomandibular joint pain on sleep patterns: Role of nitric oxide
Authors: Schutz, TCB
Andersen, M. L.
Tufik, S.
Universidade Federal de São Paulo (UNIFESP)
Keywords: orofacial pain
nitric oxide
Issue Date: 1-Sep-2004
Publisher: Int Amer Assoc Dental Researchi A D R/a A D R
Citation: Journal Of Dental Research. Alexandria: Int Amer Assoc Dental Researchi A D R/a A D R, v. 83, n. 9, p. 693-697, 2004.
Abstract: Since nitric oxide is related to nociception and the sleep- wake cycle, this study sought to determine its involvement in the altered sleep pattern in a temporomandibular joint pain model by investigating the effect of the inhibitor of nitric oxide synthase ( L- NAME) and that of its precursor ( L- arginine). The temporomandibular joints of test animals were injected with Freund's adjuvant or saline, and their sleep was recorded. The procedure was repeated after the administration of L- NAME and L- arginine. L-NAME increased rapid eye movement ( REM) sleep in the control group. The orofacial pain group showed a reduction in total sleep time and an increase in sleep latency compared with the SHAM group. L- NAME increased sleep time, non- rapid eye movement ( NREM), and REM sleep and reduced sleep latency in the orofacial pain group. L- arginine did not alter sleep parameters. Thus, L- NAME improved sleep efficiency, whereas L- arginine did not modify it, suggesting the involvement of nitric oxide in painful temporomandibular joint conditions.
ISSN: 0022-0345
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Appears in Collections:Artigo

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