Please use this identifier to cite or link to this item:
|Title:||Influence of temporomandibular joint pain on sleep patterns: Role of nitric oxide|
Andersen, M. L.
Universidade Federal de São Paulo (UNIFESP)
|Publisher:||Int Amer Assoc Dental Researchi A D R/a A D R|
|Citation:||Journal Of Dental Research. Alexandria: Int Amer Assoc Dental Researchi A D R/a A D R, v. 83, n. 9, p. 693-697, 2004.|
|Abstract:||Since nitric oxide is related to nociception and the sleep- wake cycle, this study sought to determine its involvement in the altered sleep pattern in a temporomandibular joint pain model by investigating the effect of the inhibitor of nitric oxide synthase ( L- NAME) and that of its precursor ( L- arginine). The temporomandibular joints of test animals were injected with Freund's adjuvant or saline, and their sleep was recorded. The procedure was repeated after the administration of L- NAME and L- arginine. L-NAME increased rapid eye movement ( REM) sleep in the control group. The orofacial pain group showed a reduction in total sleep time and an increase in sleep latency compared with the SHAM group. L- NAME increased sleep time, non- rapid eye movement ( NREM), and REM sleep and reduced sleep latency in the orofacial pain group. L- arginine did not alter sleep parameters. Thus, L- NAME improved sleep efficiency, whereas L- arginine did not modify it, suggesting the involvement of nitric oxide in painful temporomandibular joint conditions.|
|Appears in Collections:||Artigo|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.