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Title: Clinical and laboratory characteristics of acute hepatitis C in patients with end-stage renal disease on hemodialysis
Authors: Lemos, Lara Barros [UNIFESP]
Perez, Renata de Mello [UNIFESP]
Matos, Carla Adriana Loureiro de [UNIFESP]
Silva, Ivonete S. [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Keywords: acute hepatitis C
end-stage renal disease
Issue Date: 1-Feb-2008
Publisher: Lippincott Williams & Wilkins
Citation: Journal Of Clinical Gastroenterology. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 2, p. 208-211, 2008.
Abstract: Background: Patients with end-stage renal disease (ESRD) undergoing hemodialysis are a risk group for hepatitis C virus (HCV) infection. The characteristics of acute hepatitis C infection in this population are not well known.Goals: To evaluate the clinical and laboratory characteristics of acute hepatitis C in ESRD patients treated with hemodialysis.Study: ESRD patients on hemodialysis with acute hepatitis C, characterized by elevated alanine aminotransferase (ALT) followed by anti-HCV seroconversion were studied.Results: Thirty-six patients (58% females, 44 +/- 12 y), with a mean time on hemodialysis of 2 years, were included. Only 2 (6%) patients had jaundice. ALT elevation was observed in all patients. Median peak ALT was 4.7 x upper limit of normal. The median interval between ALT elevation and anti-HCV seroconversion was I month (0 to 8). None of the patients with detectable HCV-RNA showed spontaneous clearance of viremia within 12 weeks of follow-up. Three (8%) patients presented ALT elevation followed by anti-HCV seroconversion with undetectable HCV-RNA.Conclusions: Acute hepatitis C is frequently asymptomatic in ESRD patients on hemodialysis and should be suspected in all patients presenting elevated ALT. Determination of HCV-RNA is important for the confirmation of infection. Anti-HCV seroconversion seems to occur early and spontaneous clearance of HCV-RNA is uncommon.
ISSN: 0192-0790
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