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Title: Antimicrobial susceptibility profile of contemporary clinical strains of Stenotrophomonas maltophilia isolates: Can moxifloxacin activity be predicted by levofloxacin MIC results?
Authors: Gales, Ana Cristina [UNIFESP]
Jones, R. N.
Sader, Helio Silva [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
JMI Labs
Keywords: Stenotrophomonas maltophilia
in vitro activity
SENTRY Program
Issue Date: 1-Feb-2008
Publisher: Esift Srl
Citation: Journal Of Chemotherapy. Florence: Esift Srl, v. 20, n. 1, p. 38-42, 2008.
Abstract: The susceptibility profile of 763 Stenotrophomonas maltophilia isolates was evaluated against 16 antimicrobials by the CLSI reference broth microdilution method. Minocycline (MIC90, 1 mu g/ml; 100.0% susceptible) was the most active compound, followed by doxycycline (MIC90, 4 mu g/ml; 99.6% susceptible), trimethoprim/sulfamethoxazole (MIC90, 1 mu g/ml; 97.8% susceptible), and tigecycline (MIC 90, 2 mu g/ml). An excellent correlation between levofloxacin (MIC90, 4 mu g/ml; 86.5% susceptible by published breakpoint criteria) and moxifloxacin (MIC90, 2 mu g/ml) MIC results was observed indicating that moxifloxacin could be further evaluated as a therapeutic option for S. maltophilia infections.
ISSN: 1120-009X
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Appears in Collections:Artigo

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