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Title: Apolipoprotein E4 allele and ribosomal genes in Alzheimer's disease
Authors: Tavares, W. M.
Speranca, M. A.
Labio, Roger Willian de
Peres, Clovis de Araujo [UNIFESP]
Okamoto, Ivan Hideyo [UNIFESP]
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Smith, Marilia de Arruda Cardoso [UNIFESP]
Payão, Spencer Luiz Marques [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: ageing
Alzheimer's disease
ribosomal genes
apolipoprotein E
Issue Date: 1-Aug-2004
Publisher: Ios Press
Citation: Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 6, n. 4, p. 391-395, 2004.
Abstract: Ribosomal genes are involved in cellular transcription, translation and gene expression modulation process. An association between 28S/18S rRNA ratio levels with apoptosis and aging has been reported. Moulder et al. [22] and Hashimoto et al. [8] showed an association between apolipoprotein E4 allele and neuronal cell apotosis through diverse mechanisms. The apoE 4 allele is considered a late-onset Alzheimer's disease (AD) risk factor associated with AD pathogenesis. We evaluated the association between apoE4 allele genotyping by PCR and rRNA 28S/18S ratio by slot blotting technique using peripheral blood samples of 18 Alzheimer's disease patients, 18 elderly controls and 18 young controls. A rRNA ratio decrease was observed in AD individuals confirming our previous results but this association is independently of the ApoE4 allele genotype. Thus our results pointed that two different mechanisms are involved in the etiology of Alzheimer disease each one leading independently to cell death. Further studies could investigate these factors.
ISSN: 1387-2877
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Appears in Collections:Artigo

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