Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/44173
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dc.contributor.authorSilva, Patricia Natalia Oliveira da [UNIFESP]
dc.contributor.authorGigek, Carolina Oliveira [UNIFESP]
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorBertolucci, Paulo Henrique Ferreira [UNIFESP]
dc.contributor.authorLabio, Roger Willian de
dc.contributor.authorPayão, Spencer Luiz Marques [UNIFESP]
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.date.accessioned2018-06-15T17:53:01Z-
dc.date.available2018-06-15T17:53:01Z-
dc.date.issued2008-01-01
dc.identifierhttp://dx.doi.org/10.3233/JAD-2008-13207
dc.identifier.citationJournal Of Alzheimers Disease. Amsterdam: Ios Press, v. 13, n. 2, p. 173-176, 2008.
dc.identifier.issn1387-2877
dc.identifier.urihttp://repositorio.unifesp.br/11600/44173-
dc.description.abstractLongevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease ( AD). Methylation Specifc PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p > 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p = 0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis.en
dc.format.extent173-176
dc.language.isoeng
dc.publisherIos Press
dc.relation.ispartofJournal Of Alzheimers Disease
dc.rightsAcesso restrito
dc.subjectagingen
dc.subjectAlzheimer's diseaseen
dc.subjectCDH1en
dc.subjectDNA methylationen
dc.subjectepigeneticsen
dc.subjectHTERTen
dc.subjectSIRT3en
dc.subjectSMARCA5en
dc.titlePromoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's diseaseen
dc.typeArtigo
dc.rights.licensehttp://www.iospress.nl/service/authors/author-copyright-agreement/
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFAMEMA
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol,Genet Div, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Neurol, Dept Clin Neurol, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationFAMEMA, Hemocentro, Marilia, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Genet, Dept Morfol,Genet Div, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Neurol, Dept Clin Neurol, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.identifier.doi10.3233/JAD-2008-13207
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000254303500007
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Artigo

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