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Title: The bone marrow cells radioprotection by amifostine - NN/N ratio, apoptosis, ultrastructural and lipid matrix evaluation
Authors: Segreto, Roberto Araujo [UNIFESP]
Egami, Mizue Imoto [UNIFESP]
França, Jerônimo Pereira de [UNIFESP]
Silva, MRR
Ferreira, Alice Teixeira [UNIFESP]
Segreto, Helena Regina Comodo [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: bone marrow
ionizing radiation
Issue Date: 1-Apr-1999
Publisher: Interciencia
Citation: Interciencia. Caracas: Interciencia, v. 24, n. 2, p. 127-134, 1999.
Abstract: The present experiment was performed in order to estimate the amifostine-WR2721 (ami) bone marrow cells radioprotection, by the following parameters. NN/N ratio, the apoptotic cell counting, ultrastructural analysis and lipid matrix (membrane) injury evaluation.The protected marrows showed: significant low NN/N ratio (24h); significant low number of apoptotic cells (4,12h); better ultrastructural aspect (4,12,24h and 10 days); less lipid matrix injury (4h). These findings show that amifostine is an efficient radioprotector for the bone marrow cells.
ISSN: 0378-1844
Appears in Collections:Artigo

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