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Title: Expression of galectin-3 in gastric adenocarcinoma
Authors: Gomes, Thiago Simao [UNIFESP]
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Forones, Nora Manoukian [UNIFESP]
Lima, Flavio de Oliveira [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Biomarker
gastric adenocarcinoma
Issue Date: 1-Jul-2014
Publisher: Indian Council Medical Res
Citation: Indian Journal Of Medical Research. New Delhi: Indian Council Medical Res, v. 140, p. 69-76, 2014.
Abstract: Background & objectives: Galectin-3 a member of the galectin family is an endogenous beta-galactoside binding lectin. It has been found to be associated with cell adhesion, recognition, proliferation, differentiation, immunomodulation, angiogenesis, apoptosis and can be a reliable marker for cancer aggressiveness. The aim of this study was to verify protein expression in gastric adenocarcinoma tissues and correlate the results with the clinical aspects in the study population.Methods: Galectin-3 expression was examined by immunohistochemistry in 57 samples of gastric adenocarcinomas tissues. Galectin-3 protein expression was observed in the cytoplasm and the nucleus of examined tissues.Results: Thirty one (54.4%) samples had strong or moderate staining and 26 (45.6%) tumours had negative or weak staining. The galectin-3 did not show association with the sex (p=0.347), age (p=0.999), Lauren's classification (p=0.731) and TNM stage (p=0.222). Regarding the TNM stage, 66.7 per cent of stage I tumours had strong or moderate staining; with tumours stage IV this percentage was 33.3 per cent.Interpretation & conclusion: Our results suggest that gal-3 is not a reliable biomarker for prognosis of the gastric adenocarcinoma by immunohistochemistry. Further studies need to be done on a large sample of tumour tissues in different clinical staging.
ISSN: 0971-5916
Other Identifiers:;year=2014;volume=140;issue=1;spage=69;epage=76;aulast=Gomes;type=0
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