Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/43917
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dc.contributor.authorNoguti, Juliana [UNIFESP]
dc.contributor.authorBarbisan, Luis Fernando
dc.contributor.authorCesar, Augusto [UNIFESP]
dc.contributor.authorPereira, Camilo Dias Seabra [UNIFESP]
dc.contributor.authorChoueri, Rodrigo Brasil [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.date.accessioned2018-06-15T17:38:31Z
dc.date.available2018-06-15T17:38:31Z
dc.date.issued2012-07-01
dc.identifierhttp://iv.iiarjournals.org/content/26/4/647.full
dc.identifier.citationIn Vivo. Athens: Int Inst Anticancer Research, v. 26, n. 4, p. 647-650, 2012.
dc.identifier.issn0258-851X
dc.identifier.urihttp://repositorio.unifesp.br/11600/43917
dc.description.abstractThe Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk.en
dc.format.extent647-650
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofIn Vivo
dc.rightsAcesso aberto
dc.subjectCanceren
dc.subjectin vivo modelsen
dc.subjectGST-P 7-7en
dc.subjectreviewen
dc.titleIn Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesisen
dc.typeResenha
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Fed Sao Paulo, Univ Fed Sao Paulo, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUNESP, Sao Paulo State Univ, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Univ Fed Sao Paulo, Dept Biosci, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000306397000018
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