Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/43728
Title: INVESTIGATION OF THE NUCLEOLAR ORGANIZER REGIONS IN ALZHEIMERS-DISEASE
Authors: Payão, Spencer Luiz Marques [UNIFESP]
Smith, MDC
Kormann-Bortolotto, Maria Helena [UNIFESP]
Toniolo Neto, João [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: ALZHEIMERS DISEASE
CHROMOSOME 21
NUCLEOLUS ORGANIZER REGIONS
RIBOSOMAL GENES
SATELLITE ASSOCIATION
Issue Date: 1-Jan-1994
Publisher: Karger
Citation: Gerontology. Basel: Karger, v. 40, n. 1, p. 13-17, 1994.
Abstract: The Ag-stained nucleolus organizer regions and the satellite association (SA) were studied in peripheral lymphocyte cultures derived from 10 patients with Alzheimer's disease (AD), 10 elderly controls and 10 young controls. Our results showed a significant lower frequency of Ag staining and SA in relation to the chromosome pair 21 in the AD patient group when compared with the elderly and young control groups. These results point to a reduction in the activity of ribosomal genes in the AD patient group.
URI: http://repositorio.unifesp.br/11600/43728
ISSN: 0304-324X
Other Identifiers: https://doi.org/10.1159/000213569
Appears in Collections:Artigo

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