Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/43604
Title: Immunohistochemical expression of granzyme B and vascular endothelial growth factor (VEGF) in normal uterine cervices and low and high grade squamous intraepithelial lesions
Authors: Mattos, Patricia Napoli Belfort [UNIFESP]
Focchi, Gustavo Rubino de Azevedo [UNIFESP]
Speck, Neila Maria de Góis [UNIFESP]
Taha, Nabiha Saadi Abrahão [UNIFESP]
Carvalho, Carmen Regina Nogueira de [UNIFESP]
Ribalta, Julisa Chamorro Lascasas [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Granzyme B
VEGF
CIN 1
CIN 2
CIN 3
Issue Date: 1-Jan-2010
Publisher: I R O G Canada, Inc
Citation: European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 31, n. 4, p. 459-461, 2010.
Abstract: Purpose: This study aimed to evaluate the immunoexpression of granzyme B and vascular endothelial growth factor (VEGF) in the variants of cervical squamous intraepithelial neoplasia. Methods: Granzyme B immunohistochemical expression was studied in the epithelium, stroma and in both the epithelium + stroma of 142 fragments of uterine cervix; there were 34 grade 1 cervical intraepithelial neoplasias (CIN 1), 36 grade 2 cervical intraepithelial neoplasias (CIN 2), 33 grade 3 cervical intraepithelial neoplasias (CIN 3) and 39 uterine cervix fragments without abnormalities - control group. Immunoexpression of VEGF was studied in 160 uterine cervix fragments, with 43 grade 1 cervical intraepithelial neoplasias (CIN 1), 33 grade 2 cervical intraepithelial neoplasias (CIN 2), 31 grade 3 cervical intraepithelial neoplasias (CIN 3) and 53 uterine cervix fragments without abnormalities - control group. Results: In the stroma, immunoexpression of granzyme B in grade 1 cervical intraepithelial neoplasias was smaller than in grade 3 cervical intraepithelial neoplasias. High VEGF immunoexpression was found in grade 3 cervical intraepithelial neoplasias while it was low in grade I cervical intraepithelial neoplasias and in the control group. Conclusion: The higher the severity of the cervical intraepithelial lesion, the higher the immunoexpression of granzyme B. A progressive increase in VEGF immunoexpression was found in the intense grade, according to the severity of the cervical intraepithelial neoplasia.
URI: http://repositorio.unifesp.br/11600/43604
ISSN: 0392-2936
Other Identifiers: http://www.irog.net/download/?magazine=82
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