Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/43484
Title: Proinsulin and insulin levels according to glucose tolerance among Japanese-Brazilians, aged 40-79 years
Authors: Iochida, Lucia Christina [UNIFESP]
Marcopito, Luiz Francisco [UNIFESP]
Franco, Laercio Joel [UNIFESP]
Ferreira, Sandra Roberta Gouvea [UNIFESP]
Iunes, Magid [UNIFESP]
Dalbosco, Ivaldir Sabino [UNIFESP]
Russo, Ewaldo Mario Kuhlmann [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
UNIV FED RIO GRANDE
Keywords: diabetes mellitus
insulin
proinsulin
glucose tolerance
immunofluorimetric assay
Issue Date: 1-Oct-1996
Publisher: Elsevier B.V.
Citation: Diabetes Research And Clinical Practice. Clare: Elsevier Sci Ireland Ltd, v. 34, p. S31-S35, 1996.
Abstract: This study of the Japanese-Brazilians living in Bauru, Sao Paulo, Brazil, aimed at determining the prevalence of DM in the first (Issei) and second (Nisei) generations, according to WHO criteria. Insulin and proinsulin were determined by new immunofluorimetric assays (IMFA), that, measure true insulin and intact proinsulin, at fasting and 2 h after glucose load. The data showed a very scattered distribution, so only medians are shown and no statistical testing applied. There was a tendency for higher fasting proinsulin levels in the diabetic groups. The highest fasting proinsulin levels were seen in the diabetic patients, Either obese or non-obese. The post-load insulin levels were higher in diabetic and IGT individuals, compared to normals. Both generations showed a distinct behaviour for the obese and non-obese groups. and no major differences were observed between generations. This population seems to be sensitive to environmental changes, since the obese groups showed the higher levels of proinsulin and insulin. In the evaluation of the role of the environmental factors in the pathogenesis of DM, proinsulin and insulin levels could act as early markers of pancreatic dysfunctions.
URI: http://repositorio.unifesp.br/11600/43484
ISSN: 0168-8227
Other Identifiers: http://dx.doi.org/10.1016/S0168-8227(96)90005-4
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