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Title: Chronic Infusion of Amyloid-beta Peptide and Sustained Attention Altered alpha 7 Nicotinic Receptor Density in the Rat Brain
Authors: Viel, Tania Araujo [UNIFESP]
Caetano, Ariadiny Lima
Albuquerque, Marilia Silva
Araujo, Mariana da Silva [UNIFESP]
Buck, Hudson de Sousa [UNIFESP]
Universidade de São Paulo (USP)
Fac Ciencias Med Santa Casa Sao Paulo
Universidade Federal de São Paulo (UNIFESP)
Keywords: Alpha7 nicotinic receptor
Issue Date: 1-Dec-2012
Publisher: Bentham Science Publ Ltd
Citation: Current Alzheimer Research. Sharjah: Bentham Science Publ Ltd, v. 9, n. 10, p. 1210-1220, 2012.
Abstract: It is already known that progressive degeneration of cholinergic neurons in brain areas such as the hippocampus and the cortex leads to memory deficits, as observed in Alzheimer's disease. This work verified the effects of the infusion of amyloid-beta (A beta) peptide associated to an attentional rehearsal on the density of alpha 7 nicotinic cholinergic receptor (nAChR) in the brain of male Wistar rats. Animals received intracerebroventricular infusion of A beta or vehicle (control - C) and their attention was stimulated weekly (Stimulated A beta group: S-A beta and Stimulated Control group: SC) or not (Non-Stimulated A beta group: N-SA beta and Non-Stimulated Control group: N-SC), using an active avoidance apparatus. Conditioned avoidance responses (CAR) were registered. Chronic infusion of A beta caused a 37% reduction in CAR for N-SA beta. In S-A beta, this reduction was not observed. At the end, brains were extracted and autoradiography for alpha 7 nAChR was conducted using [I-125]-alpha-bungarotoxin. There was an increase in alpha 7 density in hippocampus, cortex and amygdala of SA beta animals, together with the memory preservation. In recent findings from our lab using mice infused with A beta and the alpha 7 antagonist methyllycaconitine, and stimulated weekly in the same apparatus, it was observed that memory maintenance was abolished. So, the increase in alpha 7 density in brain areas related to memory might be related to a participation of this receptor in the long-lasting change in synaptic plasticity, which is important to improve and maintain memory consolidation.
ISSN: 1567-2050
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