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Title: Early Onset Obsessive-Compulsive Disorder With and Without Tics
Authors: Mathis, Maria Alice de
Diniz, Juliana B.
Shavitt, Roseli G.
Torres, Albina Rodrigues [UNIFESP]
Ferrao, Ygor A.
Fossaluza, Victor [UNIFESP]
Pereira, Carlos
Miguel, Euripedes Constantino
Rosario, Maria Conceicao do [UNIFESP]
Universidade de São Paulo (USP)
Botucatu Med Sch
Ctr Univ Metodista
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jul-2009
Publisher: M B L Communications, Inc
Citation: Cns Spectrums. New York: M B L Communications, Inc, v. 14, n. 7, p. 362-370, 2009.
Abstract: Introduction: Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations.Objective: The aims of this study were to compare clinical and demographic characteristics of OCD patients with early and late age of onset of obsessive-compulsive symptoms (OCS); and to compare the same features in early onset OCD with and without tics. The independent impact of age at onset and presence of tics on comorbidity patterns was investigated.Methods: Three hundred and thirty consecutive outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for OCD were evaluated: 160 patients belonged to the early onset group (EOG): before 11 years of age, 75 patients had an intermediate onset (IOG), and 95 patients were from the late onset group (LOG): after 18 years of age. From the 160 EOG, 60 had comorbidity with tic disorders. The diagnostic instruments used were: the Yale-Brown Obsessive Compulsive Scale and the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS), Yale Global Tics Severity Scale; and Structured Clinical Interview for DSM-IV Axis I Disorders-patient edition. Statistical tests used were: Mann-Whitney, full Bayesian significance test, and logistic regression.Results: The EOG had a predominance of males, higher frequency of family history of OCS, higher mean scores on the aggression/violence and miscellaneous dimensions, and higher mean global DY-BOCS scores. Patients with EOG without tic disorders presented higher mean global DY-BOCS scores and higher mean scores in the contamination/cleaning dimension.Conclusion: The current results disentangle some of the clinical overlap between early onset OCD with and without tics. CNS Spectr. 2009; 14(7):362-370
ISSN: 1092-8529
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