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Title: Obsessive-compulsive disorder: An open-label pilot trial of escitalopram
Authors: Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP]
Quarantini, Lucas de Castro [UNIFESP]
Gois, Cristianne R.
Santos-Jesus, Rogerio
Miranda-Scippa, Ângela Marisa de Aquino [UNIFESP]
Oliveira, Irismar R. de
Prado, Helena da Silva [UNIFESP]
Leckman, James F.
Rosario, Maria Conceicao do [UNIFESP]
Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Yale Univ
Issue Date: 1-Jul-2007
Publisher: M B L Communications, Inc
Citation: Cns Spectrums. New York: M B L Communications, Inc, v. 12, n. 7, p. 519-524, 2007.
Abstract: Introduction: Selective serotonin reuptake inhibitors are considered the most effective and well-established pharmacotherapy for the treatment of obsessive-compulsive disorder (OCD), a chronic and disabling condition. However, similar to 40% of patients do not have a significant improvement, suggesting that new medications are needed. This study was designed to investigate the treatment response to escitalopram in OCD patients.Methods: This open-label study involved 11 adult OCD outpatients diagnosed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders. Data were collected and the treatment response was assessed by an experienced psychiatrist by using the Yale-Brown Obsessive-Compulsive Scale. Subjects received escitalopram 30 mg/day for 12 weeks starting at 10 mg/day. Dosage adjustments were made within 2 weeks, depending on the tolerability of the patient.Results: Six of the 11 patients (54.5%) presented a reduction of at least 40% in the baseline total Yale-Brown Obsessive-Compulsive Scale scores.Conclusion: Despite the small sample size and the open-label nature of this trial, these data suggest that escitalopram may be a useful option for patients with OCD.
ISSN: 1092-8529
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Appears in Collections:Artigo

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