Please use this identifier to cite or link to this item:
|Title:||Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders An In Vivo Study of Dopamine Transporters Using Tc-99m-TRODAT-1 SPECT|
Szobot, Claudia M.
Shih, Ming Chi [UNIFESP]
Hoexter, Marcelo Queiroz [UNIFESP]
Anselmi, Carlos Eduardo
Bressan, Rodrigo Affonseca [UNIFESP]
Rohde, Luis Augusto
Complexo Hosp Santa Casa LAMENU
Universidade Federal de São Paulo (UNIFESP)
Univ Fed RGS UFRGS
Univ Luterana Brasil
Inst Nacl Psiquiatria Desenvolvimento
substance use disorders
|Publisher:||Lippincott Williams & Wilkins|
|Citation:||Clinical Nuclear Medicine. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 2, p. E129-E134, 2014.|
|Abstract:||Purpose: Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders (SUD) frequently co-occur. Although several studies have shown changes in striatal dopamine transporter (DAT) density in these disorders, little is known about the neurobiological basis of the comorbidity. The aim of this study was to evaluate striatal DAT density in treatment-naive ADHD adolescents with SUD (ADHD + SUD) and without SUD (ADHD), compared to SUD adolescents without ADHD (SUD) and healthy control subjects (HC).Patients and Methods: Sixty-two male age-matched subjects diagnosed with DSM-IV criteria were included: ADHD + SUD (n = 18), SUD (n = 14), HC (n = 19), and ADHD (n = 11). Urine tests confirmed participants' drug use. All subjects performed SPECT scans with Tc-99m-TRODAT-1 to evaluate DAT density in the striatum.Results: The mean right striatum specific binding were 1.68 (ADHD), 1.38 (ADHD + SUD), 1.19 (HC), 1.17 (SUD), and in left striatum 1.65 (ADHD), 1.39 (ADHD + SUD), 1.19 (HC), and 1.17 (SUD). The ADHD group presented significantly higher striatal DAT density compared with ADHD + SUD, SUD, and HC groups. Adolescents with ADHD + SUD had significantly lower DAT density than those with ADHD, but significantly higher DAT density than those with SUD only and no significant difference from the healthy control group.Conclusion: The ADHD + SUD group had lower striatal DAT density in comparison with ADHD without SUD. It is possible to speculate that the use of cannabis and cocaine is responsible for the lower striatal DAT density in this group which would help in understanding the neurobiological basis for the self-medication theory in ADHD adolescents.|
|Appears in Collections:||Artigo|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.