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Title: Takayasu arteritis in a Brazilian multicentre study: children with a longer diagnosis delay than adolescents
Authors: Clemente, Gleice [UNIFESP]
Hilário, Maria Odete Esteves [UNIFESP]
Lederman, Henrique Manoel [UNIFESP]
Silva, C. A.
Sallum, A. M.
Campos, L. M.
Sacchetti, S.
Santos, M. C. dos
Ferriani, Virginia Paes Leme [UNIFESP]
Sztajnbok, F.
Gasparello, R.
Oliveira, S. Knupp
Lessa, M.
Bica, B.
Cavalcanti, A.
Robazzi, T.
Bandeira, M.
Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Santa Casa Misericordia Sao Paulo
Universidade do Estado do Rio de Janeiro (UERJ)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de Pernambuco (UFPE)
Universidade Federal da Bahia (UFBA)
Hosp Pequeno Principe
Keywords: Takayasu arteritis
Issue Date: 1-May-2014
Publisher: Clinical & Exper Rheumatology
Citation: Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 32, n. 2, p. S128-S133, 2014.
Abstract: Objective. To evaluate and compare demographic, clinical, laboratory and angiographic data of Brazilian children and adolescents with Takayasu's arteritis.Methods. In this Brazilian multicentre, retrospective study which included 10 paediatric rheumatology centres, we identified 71 children and adolescents with Takayasu's arteritis which were diagnosed before their 19th birthday. The patients' demographic, clinical, laboratorial and angiographic data were recorded. The participants were divided into two groups: children, defined by the WHO as younger than 10 years old (group 1: 36 patients) and adolescents, defined as individuals aged 10 to 19 years old (group 2: 35 patients). Features of both groups concerning disease manifestations were compared.Results. A total of 21 (58.3%) patients in group 1 and 30 (85.7%) patients in group 2 were girls (p=0.01). The mean age at disease onset, the mean time to diagnosis, and the mean follow-up time were 5.7 and 12.7, 1.8 and 0.7, 7.2 and 3.6 years, respectively, in groups 1 and 2 (p<0.001, 0.001 and <0.001). At initial evaluation, constitutional symptoms (77.5%) were the most predominant symptoms and decreased peripheral pulses (85.9%) was the most predominant clinical sign without differences between groups. The main laboratory findings were increased erythrocyte sedimentation rate followed by leukocytosis. Anaemia, thrombocytosis and higher platelet levels were significantly more frequent in group 1 (p=0.031, 0.001 and 0.018). Angiographic data were similar in both groups.Conclusion. Children presented more laboratory abnormalities but clinical and angio graphic characteristics were similar to those presented by the adolescents. Diagnosis delay is longer in younger patients.
ISSN: 0392-856X
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Appears in Collections:Artigo

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