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Title: Chronic action of association of zidovudine, lamivudine and ritonavir on pregnant rats. A biologic assay
Authors: Wagner, A.
Nakamura, Mary Uchiyama [UNIFESP]
Simoes, Ricardo Santos [UNIFESP]
Oliveira-Filho, Ricardo Martins [UNIFESP]
Fontes, Tereza Maria Pereira [UNIFESP]
Carvalho, Luisa Patricia Fogarolli de [UNIFESP]
Espiridião, Silvia [UNIFESP]
Kulay Júnior, Luiz [UNIFESP]
Univ Jose do Rosario Vellano
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Rat
Issue Date: 1-Jan-2011
Publisher: I R O G Canada, Inc
Citation: Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 38, n. 1, p. 28-32, 2011.
Abstract: Purpose: To evaluate at term the effects of a highly active antiretroviral (HAAR) drug association administered during the entire period of rat pregnancy. Methods: Three groups (n = 10 each) of adult pregnant rats were treated with an oral solution of HAAR (Exp 1 = 10/5/20 mg/kg b.w.; Exp 2 = 30/15/60 mg/kg b.w.; Exp 3 = 90/45/180 mg/kg b.w.) from day 0 up to the 20th day of pregnancy. A fourth group served as a control. At term (20th day) the rats were killed under deep anesthesia and the number of implantations, resorptions, living fetuses, placentae and intrauterine deaths were recorded. Results: The highest HAAR doses caused lower maternal weight gain, lower litter weights, and lower placental weights compared to the control group. Conclusions: HAAR during the entire period of rat pregnancy can reduce maternal body weight gain and lower term placental weight.
ISSN: 0390-6663
Appears in Collections:Artigo

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