Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/43132
Title: Gastroesophageal reflux episodes in asthmatic patients and their temporal relation with sleep architecture
Authors: Mello-Fujita, Luciane [UNIFESP]
Roizenblatt, Suely [UNIFESP]
Frison, Claudio Ricardo [UNIFESP]
Rodrigues, L. [UNIFESP]
Garbuio, Silvério Aparecido [UNIFESP]
Tufik, Sergio [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: asthma
gastroesophageal reflux
polysomnography
sleep
Issue Date: 1-Feb-2008
Publisher: Assoc Bras Divulg Cientifica
Citation: Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 41, n. 2, p. 152-158, 2008.
Abstract: Gastroesophageal reflux (GER) is common in asthma patients and can contribute to sleep disruption. The aim of the present study was to determine the time-related distribution of GER events together with their impact on sleep in asthmatic subjects with GER disease symptoms. The inclusion criteria were: 18-65 years, controlled moderate to severe asthma and GER-compatible clinical evidence. The exclusion criteria were: chronic obstructive lung disease, smoking, infections of the upper airways, use of oral corticosteroids, other co-morbidities, pregnancy, sleep-related disorders, night-time shift work, and the use of substances with impact on sleep. Asthmatic patients with nocturnal symptoms were excluded. All-night polysomnography and esophageal pH monitoring were recorded simultaneously. Of the 147 subjects selected, 31 patients and 31 controls were included. Seventeen patients were classified as DeMeester positive and 14 as DeMeester negative. Both groups displayed similar outcomes when general variables were considered. Sleep stage modification one minute prior to GER was observed in the DeMeester-positive group. Awakening was the most frequent occurrence at GER onset and during the 1-min period preceding 38% of the nocturnal GER. Sleep stage 2 was also prevalent and preceded 36% of GER events. In the DeMeester-negative group, awakening was the most frequent response before and during GER. Modifications in sleep stages, arousals or awakenings were associated with 75% of the total GER events analyzed during the period of one minute before and after the fall of esophageal pH below 4 in the DeMeester-positive group. These data provide evidence that sleep modifications precede the GER events in asthmatic patients.
URI: http://repositorio.unifesp.br/11600/43132
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/S0100-879X2008000200012
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