Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/43095
Full metadata record
DC FieldValueLanguage
dc.contributor.authorColleoni, Gisele Wally Braga [UNIFESP]
dc.contributor.authorCosta, F. F.
dc.contributor.authorGrignolli, CRE
dc.contributor.authorSilva, R. S.
dc.contributor.authorChauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
dc.contributor.authorKerbauy, José [UNIFESP]
dc.contributor.authorSaad, Sara Teresinha Olalla [UNIFESP]
dc.date.accessioned2018-06-15T16:23:57Z-
dc.date.available2018-06-15T16:23:57Z-
dc.date.issued1996-10-01
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 29, n. 10, p. 1307-1310, 1996.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/11600/43095-
dc.description.abstractChronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence of a reciprocal translocation between chromosomes 9 and 22 in at least 95% of cases. At the molecular level, this translocation results in the activation of the ABL oncogene of chromosome 9, which becomes contiguous with the 5' end of the BCR gene on chromosome 22. The breakpoint usually occurs between exons 2 and 3 (b2-a2 rearrangement), or 3 and 4 (b3-a2 rearrangement) of the major breakpoint cluster region (M-BCR) of the BCR gene. The aim of the present study was to characterize the type of BCR-ABL transcript in 32 patients with CML using the reverse transcriptase-polymerase chain reaction (RT-PCR) and to determine if this type of rearrangement is related to the survival of the patients. Our results confirmed that RT-PCR is more sensitive than cytogenetic analysis for identifying the Philadelphia (Ph1) chromosome (96.9% vs 79.3%). The frequencies of b2-a2 and b3-a2 rearrangements were 28.1% and 65.7%, respectively. The survival of patients presenting the b2-a2 or the b3-a2 rearrangement was not significantly different (P = 0.27750). The data suggest that the type of transcript has no prognostic value for CML patients.en
dc.format.extent1307-1310
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsAcesso restrito
dc.subjectchronic myeloid leukemiaen
dc.subjectphiladelphia chromosomeen
dc.subjectpolymerase chain reactionen
dc.subjectBCR-ABL rearrangementen
dc.titlePrognostic significance of BCR-ABL rearrangement in chronic myeloid leukemiaen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUNIV ESTADUAL CAMPINAS, DEPT CLIN MED, BR-13081970 CAMPINAS, SP, BRAZIL
dc.description.affiliationUNIV ESTADUAL CAMPINAS, HEMOCTR, BR-13081970 CAMPINAS, SP, BRAZIL
dc.description.affiliationUNIV FED SAO PAULO, DISCIPLINA HEMATOL, BR-04023900 SAO PAULO, BRAZIL
dc.description.affiliationUNIV FED SAO PAULO, DEPT ESTATIST, BR-04023900 SAO PAULO, BRAZIL
dc.description.affiliationUnifespUNIV FED SAO PAULO, DISCIPLINA HEMATOL, BR-04023900 SAO PAULO, BRAZIL
dc.description.affiliationUnifespUNIV FED SAO PAULO, DEPT ESTATIST, BR-04023900 SAO PAULO, BRAZIL
dc.description.sourceWeb of Science
dc.identifier.wosWOS:A1996VM71000008
Appears in Collections:Artigo

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.