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|Title:||BLOOD-GLUCOSE AND INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE BY PATIENTS WITH CHRONIC CHAGAS-DISEASE AND ALCOHOLISM|
Juliano, Yara [UNIFESP]
Novo, Neil Ferreira [UNIFESP]
Neves, Manoel Martins das [UNIFESP]
Universidade Federal de Uberlândia (UFU)
Universidade Federal de São Paulo (UNIFESP)
|Publisher:||Assoc Bras Divulg Cientifica|
|Citation:||Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 26, n. 11, p. 1187-1190, 1993.|
|Abstract:||Blood glucose and insulin responses to intravenous glucose 500 mg/kg in a group of alcoholic chagasic patients (Group I, N = 15) were assessed and compared to those of a group of patients with Chagas' disease without alcoholism (Group II, N = 16), a group of alcoholics without Chagas' disease (Group III, N = 22), and a group of non-alcoholics without Chagas' disease (Group IV, N = 15). Determinations of serum glucose and insulin were done under fasting conditions, 5 and 10 min after the injection of 50% glucose. There was no difference in mean serum glucose levels between groups. Mean serum insulin levels at times 5 and 10 min and for the total integrated response were lower (P<0.05) in Groups I and II as compared to Group IV; at time 10 min the mean was lower (P<0.05) in Group III as compared to Group IV. There was a nonsignificant trend for a lower insulinemic response in Group I as compared to Group II. These data suggest denervation of or injury to pancreatic B cell by Chagas' disease.|
|Appears in Collections:||Artigo|
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