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|Title:||MEASUREMENT OF RED-BLOOD-CELL ANTIBODIES IN AUTOIMMUNE HEMOLYTIC-ANEMIA|
|Authors:||Bordin, Jose Orlando [UNIFESP]|
Souzapinto, J. C.
Kerbauy, José [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
|Keywords:||AUTOIMMUNE HEMOLYTIC ANEMIA|
ENZYME-LINKED ANTIGLOBULIN TEST
|Publisher:||Assoc Bras Divulg Cientifica|
|Citation:||Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 9, p. 895-899, 1991.|
|Abstract:||The enzyme-linked antiglobulin test (ELAT) was employed to measure the number of IgG molecules per red blood cell (IgG/RBC) in 11 patients with autoimmune hemolytic anemia (AIHA). All patients with AIHA had high levels of red cell- associated IgG (110-3,650 IgG/RBC). The control group consisted of normal volunteers (N = 10) and patients with hereditary spherocytosis (N = 1), beta-degree-thalassemia (N = 1), immunologic thrombocytopenic purpura (N = 3) and IgG multiple myeloma (N = 4). All control individuals presented low levels of red cell IgG (less than 38 IgG/RBC) with the exception of one of four patients with myeloma who had a mildly elevated value (50 IgG/RBC). Since the multiple myeloma patients had > 2g/dl IgG, the possible nonspecific uptake of IgG onto the RBCs of patients with elevated serum IgG values did not interfere with the results of ELAT. ELAT proved to be a useful method for accurate quantification of the amount of IgG specifically bound on the surface of RBC of patients with AIHA.|
|Appears in Collections:||Artigo|
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