Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/4293
Title: Antibodies to citrullinated peptides are not associated with the rate of joint destruction in patients with a well-established diagnosis of rheumatoid arthritis
Authors: Nieto-Colonia, Alberto Max [UNIFESP]
Santos, Wilton Silva dos [UNIFESP]
Keusseyan, Silene Peres [UNIFESP]
Caldana, Wanda [UNIFESP]
Fernandes, Artur da Rocha Correa [UNIFESP]
Andrade, Luiz Eduardo Coelho [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Escola Superior de Ciências da Saúde Faculdade de Medicina
Keywords: Rheumatoid arthritis
Rheumatoid factor
Autoantibodies
Citrullinated peptides
Disease severity
Joint imaging
Issue Date: 1-Mar-2008
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 3, p. 188-192, 2008.
Abstract: Antibodies to citrullinated peptides are highly specific for rheumatoid arthritis (RA) and represent a significant risk factor for undifferentiated polyarthritis. This prognostic ability may be related to the very diagnostic performance of these autoantibodies, since RA is a more erosive disease than other forms of arthritis. The present study evaluated an association of antibodies to citrullinated peptides and the rate of joint destruction in patients with a well-established diagnosis of RA. Seventy-one patients with RA were evaluated in 1994 and again in 2002 (functional class, joint count, Health Assessment Questionnaire score, hands X-ray). Autoantibodies (rheumatoid factor (RF), anti-perinuclear factor, anti-cyclic citrullinated peptide (CCP) antibodies) and Sharp's index were analyzed blindly. Delta Sharp was calculated as the difference in Sharp's index obtained in 1994 and 2002. During the follow-up the Health Assessment Questionnaire score increased from 0.91 ± 0.74 to 1.39 ± 0.72 (P < 0.001). Similarly, the number of swollen joints increased from 4.6 ± 5.71 to 6.4 ± 4.1 (P = 0.002). The frequency of autoantibodies and anti-CCP titer remained stable; however, serum RF concentration increased from 202.8 ± 357.6 to 416.6 ± 636.5 IU/mL (P = 0.003). Sharp's index increased from 56.7 ± 62.1 to 92.4 ± 80.9 (P < 0.001). No correlation was observed between Delta Sharp and the presence of RF, anti-perinuclear factor, and anti-CCP antibodies at baseline. Antibodies to citrullinated epitopes are specific and early markers for the diagnosis of RA but do not seem to be associated with the rate of joint destruction in patients with a well-established diagnosis of RA.
URI: http://repositorio.unifesp.br/handle/11600/4293
ISSN: 0100-879X
Other Identifiers: http://dx.doi.org/10.1590/S0100-879X2008005000005
Appears in Collections:Artigo

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