Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/42824
Title: Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
Authors: Moriel, Patricia
Plavnik, Frida Liane [UNIFESP]
Zanella, Maria Teresa [UNIFESP]
Bertolami, Marcelo Chiara [UNIFESP]
Abdalla, Dulcineia Saes Parra [UNIFESP]
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Inst Dante Pazzanese Cardiol
Keywords: lipoprotein oxidation
lipid peroxides
isoprostanes
antioxidants
atherosclerosis
oxidative stress
Issue Date: 1-Jan-2000
Publisher: Sociedad Biolgia Chile
Citation: Biological Research. Santiago: Sociedad Biolgia Chile, v. 33, n. 2, p. 105-112, 2000.
Abstract: Lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (HC), hypertensive (H), hypercholesterolemic/hypertensive (HH) and normolipidemic/normotensive subjects (N). Plasma ascorbate and lipid-soluble antioxidants were lower, while LDL oxidizability, CE-OOH and TL-OOH were higher in H, HC, and HH groups than in the N group. No difference was observed among groups for PL-OOH and isoprostanes. In summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the LDL susceptibility to oxidation were higher; 2) total cholesterol, LDL-cholesterol, apoB and CE-OOH were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of LDL to oxidation; and 3) CE-OOH and TL-OOH were positively correlated with total cholesterol and LDL-cholesterol.
URI: http://repositorio.unifesp.br/11600/42824
ISSN: 0716-9760
Other Identifiers: http://dx.doi.org/10.4067/S0716-97602000000200010
Appears in Collections:Artigo

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.