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Title: TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis
Other Titles: Disfunção neurossecretora de TSH na síndrome de Down: baixo risco de progressão para a tireoidite de Hashimoto
Authors: Faria, Claudia Dutra Costantin
Ribeiro, Simone
Kochi, Cristiane
Silva, Aryane Pereira Neves da
Ribeiro, Bruna Natalia Freire
Marçal, Lilian Teixeira
Santos, Felipe Henrique Yyazawa
Calliari, Luis Eduardo Procopio [UNIFESP]
Monte, Osmar
Longui, Carlos Alberto
Fac Ciencias Med Santa Casa Sao Paulo
Universidade Federal de São Paulo (UNIFESP)
Keywords: Down syndrome
Hashimoto's thyroiditis
TSH neurosecretory dysfunction
isolated TSH elevation
Issue Date: 1-Nov-2011
Publisher: Sbem-soc Brasil Endocrinologia & Metabologia
Citation: Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 55, n. 8, p. 628-631, 2011.
Abstract: Introduction: Patients with Down syndrome (DS) often have elevated TSH (hypothalamic origin), which is called TSH neurosecretory dysfunction (TSH-nd). In these cases, there is slight elevation in TSH (5-15 mu UI/mL), with normal free T4 and negative thyroid antibodies (AB). Objective: To recognize the risk of progression to Hashimoto's thyroiditis (HT). Subjects and methods: We retrospectively analyzed 40 DS patients (mean age = 4.5 years), followed up for 6.8 years. Results: HT was diagnosed in 9/40 patients, three early in monitoring, and six during evolution. In 31/40 patients, TSH-nd diagnosis remained unchanged over the years, with maximum TSH values ranging from 5 to 15 mu UI/mL. In this group, free T4 also remained normal and AB were negative. There was a significant TSH reduction (p = 0.017), and normal TSH concentrations (< 5.0 mu UI/mL) were observed in 29/31 patients, in at least one moment. No patient had TSH > 15 mu UI/mL. Conclusion: DS patients with TSH-nd present low risk of progression to HT (10% for females and 6% for males). Arq Bras Endocrinol Metab. 2011;55(8):628-31
ISSN: 0004-2730
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