Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/42643
Title: MALNUTRITION AS A PROGNOSTIC FACTOR IN LYMPHOBLASTIC-LEUKEMIA - A MULTIVARIATE-ANALYSIS
Authors: Viana, M. B.
Murao, M.
Ramos, G.
Oliveira, H. M.
Decarvalho, R. I.
Debastos, M.
Colosimo, E. A.
Silvestrini, Wagner Sérgio [UNIFESP]
Universidade Federal de Minas Gerais (UFMG)
FELICIO ROCHO HOSP
IPSEMG BASE HOSP
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Oct-1994
Publisher: British Med Journal Publ Group
Citation: Archives Of Disease In Childhood. London: British Med Journal Publ Group, v. 71, n. 4, p. 304-310, 1994.
Abstract: One hundred and twenty eight Brazilian children with lymphoblastic leukaemia were intensively treated with a Berlin-Frankfurt-Munich based protocol. More children had a white cell count above 50 x 10(9)/1 (31%) then observed in developed countries. After a median follow up of 31 months (11-58 months), the estimated probability of relapse free survival was 41% (7%) for the whole group. After adjustment in the Cox's multivariate model, malnutrition was the most significant adverse factor affecting duration of complete remission. Age above 8 years and high peripheral white cell count were also significant adverse factors. Among the nutritional indices, the height for age and weight for age z scores were both significant, whether the cut off points of z-2 or z = -1.28 were chosen to define malnutrition. A strong statistical association between the two indices was found; the contribution of height for age z score to the prediction of relapse free survival was more significant. Children with height for age z score < -2 had a relapse risk of 8.2 (95% confidence interval 3.1 to 21.9) relative to children with z score > -2. The results of this study suggest that socioeconomic and nutritional factors should be considered in the prognostic evaluation of children with leukaemia in developing countries.
URI: http://repositorio.unifesp.br/11600/42643
ISSN: 0003-9888
Other Identifiers: http://dx.doi.org/10.1136/adc.71.4.304
Appears in Collections:Artigo

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