Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/42607
Title: TREATMENT OF DISSEMINATED TORULOPSIS-GLABRATA INFECTION WITH DO870 AND AMPHOTERICIN-B
Authors: Atkinson, B. A.
Bocanegra, R.
Colombo, Arnaldo Lopes [UNIFESP]
Graybill, JR
UNIV TEXAS
AUDIE L MURPHY MEM VET ADM MED CTR
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jul-1994
Publisher: Amer Soc Microbiology
Citation: Antimicrobial Agents And Chemotherapy. Washington: Amer Soc Microbiology, v. 38, n. 7, p. 1604-1607, 1994.
Abstract: Torulopsis glabrata, an opportunist pathogen in immunosuppressed patients, is resistant to many antifungal agents, and there are no established treatment regimens for this organism. The mouse model was used to evaluate treatment with DO870, amphotericin B, fluconazole, and their combination. Mice were immunosuppressed with 5 mg of gold sodium thiomalate given intraperitoneally 1 day prior to intravenous infection with 10(8) T. glabrata cells. Treatment with a new antifungal triazole, DO870, at doses ranging from 1 to 50 mg/kg of body weight administered per os either daily or on alternate days; fluconazole at 100 mg/kg twice a day per os; or amphotericin B at 3 mg/kg/day intraperitoneally was begun 1 day after infection. Treatment for 5 days was followed by sacrifice 2 days later for determining CFU counts in spleen and kidney tissue. For a fluconazole-sensitive isolate (MIC of DO870, < 1.25 mu g/ml), DO870 at 5 mg/kg/day significantly reduced counts in kidney and spleen tissue (P < 0.05), amphotericin B was modestly effective, and the combination of DO870 (25 mg/kg) and amphotericin B (3 mg/kg) was markedly more effective than either drug alone (P < 0.01). Three additional isolates were resistant in vitro to DO870 (MIC, 4 mu g/ml). No reduction in CFU in kidney or spleen tissue was observed with DO870 when compared with counts in control tissue. DO870 is effective in vivo against at least some isolates of T. glabrata and when combined with amphotericin B can exert additive effects.
URI: http://repositorio.unifesp.br/11600/42607
ISSN: 0066-4804
Other Identifiers: http://dx.doi.org/10.1128/AAC.38.7.1604
Appears in Collections:Artigo

Files in This Item:
File SizeFormat 
WOSA1994NU59800027.pdf818.26 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.