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Title: Expression of p27, p21(WAF/Cip1) and pl6(INK4a) in Normal Oral Epithelium, Oral Squamous Papilloma, and Oral Squamous Cell Carcinoma
Authors: Queiroz, Ana Beatriz Piazza [UNIFESP]
Focchi, Gustavo Rubino de Azevedo [UNIFESP]
Dobo, Cristine [UNIFESP]
Gomes, Thiago Simao [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jul-2010
Publisher: Int Inst Anticancer Research
Citation: Anticancer Research. Athens: Int Inst Anticancer Research, v. 30, n. 7, p. 2799-2803, 2010.
Abstract: Aim: To characterize the immunohistochemical expression of p27, p21(WAF/CiP1) and p16(INK4a) in normal oral epithelium, oral squamous pcipilloma and oral squamous cell carcinoma. Materials and Methods: hnmunohistochemical staining for p27, p21(WAF/Cip1) and p16(INK4a) was evaluated in 32 samples of normal oral squamous epithelium, 30 samples of oral squamous papilloma, and 34 samples of oral squamous cell carcinoma. Results: Statistically significant differences (p<0.05) were found in p27 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples. Regarding p21(WAF/Cip1) expression, no statistically significant differences (p>0.05) were noticed. In the same way, no significant statistically differences (p>0.05) were observed for p16(INK4a) among groups. Conclusion: Taken together, these findings indicate that p27 is closely involved in malignant transformation of oral mucosa cells, and may be a reliable biomarker for this purpose.
ISSN: 0250-7005
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Appears in Collections:Artigo

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