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Title: High-dose inhaled beclomethasone treatment in patients with chronic cough: a randomized placebo-controlled study
Authors: Ribeiro, Marcos [UNIFESP]
Pereira, Carlos Alberto de Castro [UNIFESP]
Nery, Luiz Eduardo [UNIFESP]
Beppu, Osvaldo Shigueomi [UNIFESP]
Silva, Clystenes Odyr Soares [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jul-2007
Publisher: Amer Coll Allergy Asthma Immunology
Citation: Annals Of Allergy Asthma & Immunology. Arlington Hts: Amer Coll Allergy Asthma Immunology, v. 99, n. 1, p. 61-68, 2007.
Abstract: Background: It is important to determine whether chronic cough is associated with asthma and can be helped by treatment with inhaled corticosteroids.Objective: To compare the effects of beclomethasone and placebo in patients with chronic cough for at least 8 weeks after excluding those with cough due to postnasal drip and gastroesophageal reflux disease.Methods: A prospective, randomized, double-blind, placebo-controlled study comprising 64 patients was performed for 2 weeks. The active group received metered-dose inhaler chlorofluorocarbon-beclomethasone (1,500 mu g/d), and the placebo group C received identical-appearing placebo inhalers. All the participants completed a respiratory questionnaire and underwent bronc, choprovocation testing (BPT) with methacholine and allergy skin testing. The primary outcome measure was a decrease in daily cough scores (symptom diary and visual analog scale) during the 2-week treatment period.Results: The active group comprised 44 patients and the placebo group 20 patients. Cough duration averaged 20 weeks. At the end of treatment 82% of the active group and 15% of the placebo group had complete resolution of cough. In the active group 22 patients (50%) had positive BPT results, and in the placebo group 10 patients (50%) had positive results. There was no correlation between treatment response and responses on the respiratory questionnaire, allergy skin testing, or BPT.Conclusion: Therapy with high-dose inhaled beclomethasone provided an excellent response in a subgroup of patients with chronic cough that did not correlate with atopy or airway hyperresponsiveness.
ISSN: 1081-1206
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