Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/42470
Title: Selectivity of human T lymphotropic virus type-1 (HTLV-1) and HTLV-2 infection among different populations in Brazil
Authors: Gabbai, Alberto Alain [UNIFESP]
Bordin, Jose Orlando [UNIFESP]
Vieira Filho, João Paulo Botelho [UNIFESP]
Kuroda, Akemi [UNIFESP]
Oliveira, Acary Souza Bulle [UNIFESP]
Cruz, M. V.
Ribeiro, AAF
Delaney, SR
Henrard, D. R.
Rosario, J.
Roman, G. C.
ABBOTT LABS
NINCDS
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Dec-1993
Publisher: Amer Soc Trop Med & Hygiene
Citation: American Journal Of Tropical Medicine And Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 49, n. 6, p. 664-671, 1993.
Abstract: A seroprevalence study for human T lymphotropic virus type-I (HTLV-1) and HTLV-2 was conducted in Sao Paulo, Brazil among 2,312 individuals that included following groups: 1, 148 volunteer blood donors, 3 7 patients with tropical spastic paraparcsis (TSP), 53 with lymphoproliferative disorders, 171 with a history of multiple blood transfusions, 268 human immunodeficiency virus type-1 (HIV- 1) seropositive subjects, and 635 Amazonian Indians. Antibodies to HTLV-1/2 were screened by enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blot and/or radioimmunoprecipitation. The differentiation of HTLV-1 and HTLV-2 was achieved using a synthetic recombinant peptide (rgp46) ELISA. We confirmed the presence of HTLV-1 infection in Brazil, both in blood donors (0.4%) and in patients exposed to blood transfusions (2.9%), as well as the occurrence of HTLV-I-associated TSP (11 patients, or 30% of all TSP cases) and adult T cell leukemia/lymphoma (two cases, or 3.5% of all hematologic malignancies). The HIV-1 infected individuals were shown to be coinfected (8.9%) with either HTLV-1 or HTLV-2. All HIV-1 and HTLV-2 coinfected individuals were intravenous drug abusers. In addition, we also demonstrated the presence of HTLV-2 (4.7%), and HTLV-1/2 (0.8%) in tribes of Amazonian Indians who lived in the eastern Amazon basin (southeastern State of Para). The selectivity of these retroviral infections in particular groups is emphasized, as well as the need for HTLV-1/2 screening of all blood donors in Brazil as a public health measure.
URI: http://repositorio.unifesp.br/11600/42470
ISSN: 0002-9637
Other Identifiers: https://doi.org/10.4269/ajtmh.1993.49.664
Appears in Collections:Artigo

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