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Title: Arg16Gly and Gln27Glu beta 2 adrenergic polymorphisms influence cardiac autonomic modulation and baroreflex sensitivity in healthy young Brazilians
Authors: Atala, Magda M.
Goulart, Alessandra [UNIFESP]
Guerra, Grazia Maria
Mostarda, Cristiano [UNIFESP]
Rodrigues, Bruno
Mello, Priscila R.
Casarine, Dulce Elena [UNIFESP]
Irigoyen, Maria Claudia [UNIFESP]
Pereira, Alexandre C.
Consolim-Colombo, Fernanda Marciano
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Maranhao
Univ Sao Judas Tadeu
Univ Nove de Julho UNINOVE
Keywords: beta(2)-adrenergic polymorphism
autonomic nervous system
cardiac autonomic balance
heart rate variability
Issue Date: 1-Jan-2015
Publisher: E-century Publishing Corp
Citation: American Journal Of Translational Research. Madison: E-century Publishing Corp, v. 7, n. 1, p. 153-161, 2015.
Abstract: The association between functional beta(2) adrenergic receptor (beta(2)-AR) polymorphisms and cardiac autonomic modulation is still unclear. Thus, two common polymorphisms in the beta(2)-AR gene (Gln27Glu beta(2) and Arg16Gly beta(2)) were studied to determine whether they might affect tonic and reflex cardiac sympathetic activity in healthy young subjects. A total of 213 healthy young white subjects of both genders (53% female), aged 18-30 years (23.5 +/- 3.4 y), had their continuous blood pressure curves noninvasively recorded by Finometer at baseline, and other hemodynamic parameters, as cardiac autonomic modulation, baroreflex sensitivity, and allele, genotype, and diplotype frequencies calculated. Associations were made between Arg16Gly beta(2) and Gln27Glu beta(2) polymorphisms and between beta(2)-AR diplotypes and all variables. The heart rate was significantly lower (P<0.001) in the presence of homozygous Arg/Arg alleles (60.9 +/- 1.5 bpm) than in that of Arg/Gly heterozygotes (65.9 +/- 1.0 bpm) or Gly/Gly homozygotes (66.3 +/- 1.2 bpm). Homozygous carriers of Arg16 allele had an alpha index (19.2 +/- 1.3) significantly higher (P<0.001) than that of the subjects with the Gly allele Gly/Gly ( 14.5 +/- 0.7) or Arg/Gly (14.6 +/- 0.7). Furthermore, the recessive Glu27Glu and the heterozygous Gln27Glu genotypes had a higher percentage of low-frequency components (LF%) than the homozygous Gln27Gln (15.1% vs. 16.0% vs. 8.2%, P=0.03, respectively). In healthy young subjects, the presence of beta(2)-AR Arg16 allele in a recessive model was associated with higher baroreflex sensitivity, and increased parasympathetic modulation in studied individuals.
ISSN: 1943-8141
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