Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorColombari, Debora Simões de Almeida [UNIFESP]
dc.contributor.authorColombari, Eduardo [UNIFESP]
dc.contributor.authorLopes, Oswaldo Ubriaco [UNIFESP]
dc.contributor.authorCravo, Sergio Luiz [UNIFESP]
dc.identifier.citationAmerican Journal Of Physiology-regulatory Integrative And Comparative Physiology. Bethesda: Amer Physiological Soc, v. 279, n. 3, p. R884-R890, 2000.
dc.description.abstractThe role of baroreceptors, cardiopulmonary receptors, and renal nerves in the cardiovascular adjustments to volume expansion (VE) with 4% Ficoll (Pharmacia; 1% body wt, 0.4 ml/min) were studied in urethan-anesthetized rats. In control animals, VE produced a transitory increase in mean arterial pressure (MAP), which peaked at 10 min (17 +/- 4 mmHg) and increases in renal (128 +/- 6 and 169 +/- 19% of baseline at 10 and 40 min, respectively) and hindlimb vascular conductance (143 +/- 6 and 150 +/- 10%). These cardiovascular adjustments to VE were unaffected by bilateral vagotomy. After sinoaortic denervation, the increase in MAP induced by VE was greater than in control rats (30 +/- 4 mmHg). However, renal vasodilation in response to VE was blocked, whereas hindlimb vasodilation was similar to that observed in control rats. After unilateral renal denervation (ipsilateral to flow recording), the initial renal vasodilation was blocked. However, 40 min after VE, a significant renal vasodilation (125 +/- 4%) appeared. The hindlimb vasodilation and MAP responses were unaffected by renal denervation. These results demonstrate that the baroreceptor afferents are an essential component of cardiovascular adjustments to VE, especially in the control of renal vascular conductance. They also suggest that renal vasodilation induced by VE is mediated by neural and hormonal mechanisms.en
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal Of Physiology-regulatory Integrative And Comparative Physiology
dc.rightsAcesso aberto
dc.subjectblood flowen
dc.subjectcardiovascular afferentsen
dc.subjectbaroreceptor afferentsen
dc.subjectrenal nervesen
dc.titleAfferent pathways in cardiovascular adjustments induced by volume expansion in anesthetized ratsen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
Appears in Collections:Artigo

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.