Please use this identifier to cite or link to this item:
|Title:||Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal (R)) coated polypropylene mesh in rabbits|
|Authors:||Quinino, Reynaldo Martins e [UNIFESP]|
Lima, Francisco Piganataro
Barbosa, Andre Luis Costa
Maia, Tatiana de Carvalho
Goldenberg, Alberto [UNIFESP]
Rio Grande do Norte Fed Univ UFRN
Universidade Federal de São Paulo (UNIFESP)
|Publisher:||Acta Cirurgica Brasileira|
|Citation:||Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 28, n. 12, p. 807-814, 2013.|
|Abstract:||PURPOSE: To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal (R)) in contact with small bowel in an experimental model in rabbits.METHODS: Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2x1cm, in the right and left flanks. The right mesh was protected with Coseal (R) spray (Group 1) and the left mesh received no treatment after implantation (Group 2). Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test.RESULTS: There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups.CONCLUSION: Polypropylene mesh coated with Coseal (R) showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response.|
|Appears in Collections:||Artigo|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.