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Title: Apoptotic effects of inositol hexaphosphate on biomarker Itpr3 in induced colon rat carcinogenesis
Other Titles: Efeito de apoptose do inositol hexafosfato no marcador biológico Itpr3 em carcinogênese induzida de colo em ratos
Authors: Marks, Guido [UNIFESP]
Fagundes, Djalma José [UNIFESP]
Ynouye, Celso Massaschi
Pontes, Elenir Rose Jardim Cury
Takita, Luiz Carlos [UNIFESP]
Amaral, Eva Glória Abrão Siufi do [UNIFESP]
Teruya, Roberto [UNIFESP]
Paes, Manoel Catarino
Brasileiro, José Lacerda [UNIFESP]
Aydos, Ricardo Dutra [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Mato Grosso do Sul (UFMS)
Keywords: apoptosis
inositol 1,4,5 trisphosphate receptors
computer-assisted image processing
phytic acid
Issue Date: 1-Mar-2008
Publisher: Acta Cirurgica Brasileira
Citation: Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 157-164, 2008.
Abstract: Purpose: To study the effect of the modulation of inositol hexaphosphate (IP6) in the biological immunohistochemistry expression of cellular signaling marker apoptosis, in model of carcinogenesis of colon induced by azoxymethane (AOM). Methods: Wistar rats (N= 112) distributed in 4 groups (n=28): Control; B, AOM (5 mg kg(-1), 2x, to break week 3); C, IP6 (in water 1 %, six weeks); D, IP6+AOM. Weekly euthanasia (n=7), from week three. Immunohistochemistry of ascendant colon with biological marker inositol 1,4,5 triphosphate receptor type III (Itpr3). Quantification of the immune-expression with use of computer-assisted image processing. Analysis statistics of the means between groups, weeks in groups, groups in weeks, and established significance when p <= 0.05. Results: One proved significant difference between groups in the expression of Itpr3, p < 0.0001;with Itpr3 reduction of BxD group, p < 0.001. Conclusion: Inositol hexaphosphate promotes modulation of biological markers with reduction of Itpr3 in carcinogenesis of colon.
ISSN: 0102-8650
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