Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/41976
Title: Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats
Other Titles: Efeito de antiinflamatórios na integração de enxerto ósseo autógeno e de matriz óssea bovina desvitalizada em ratos
Authors: Silva, Roberto Antoniolli da [UNIFESP]
Fagundes, Djalma José [UNIFESP]
Silva, Andreia Conceicao Milan Brochado Antoniolli
Sisti, Karin Ellen
Carvalho, Themis Maria Milan Brochado de
Silva, Daniel Nunes e
Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Federal de São Paulo (UNIFESP)
Keywords: bone transplantation
anti-inflammatory agents
rats, wistar
Issue Date: 1-Mar-2008
Publisher: Acta Cirurgica Brasileira
Citation: Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 140-148, 2008.
Abstract: Purpose: To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Methods: Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had the bone defect filled with autograft and those of Group II, with bovine bone devitalized matrix. Animals of each group were redistributed to four subgroups according to the intramuscular administration of anti-inflammatory drug or saline solution: A - diclofenac sodium; B - dexamethasone; C - meloxicam; D - saline solution. Evaluation periods were 7, 14 and 30 days. Histological evaluation consisted of quantifying the inflammatory process, the bone neoformation, the collagen formation and the presence of macrophages. Results: Animals of Group I did not show significant difference considering inflammatory reaction. Significant and progressive increase of bone neoformation was observed in both groups. The animals that received meloxicam and autograft showed less collagen formation at 14 and 30 days. The number of macrophages was higher in Group II than in Group I. The animals treated with dexamethasone and saline Solution did not show statistically significant difference. Conclusions: Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it.
URI: http://repositorio.unifesp.br/11600/41976
ISSN: 0102-8650
Other Identifiers: http://dx.doi.org/10.1590/S0102-86502008000200006
Appears in Collections:Artigo

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