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Title: Lack of association between matrix metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma
Authors: Piccoli, Michelly F. [UNIFESP]
Figueira, Marcia [UNIFESP]
Andreoni, Cássio [UNIFESP]
Marumo, Julio T. [UNIFESP]
Schor, Nestor [UNIFESP]
Bellini, Maria H. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: MMP-1
renal cell carcinoma
Issue Date: 1-Oct-2007
Publisher: Sociedade Brasileira de Urologia
Citation: International braz j urol. Sociedade Brasileira de Urologia, v. 33, n. 5, p. 622-629, 2007.
Abstract: OBJECTIVE: Investigate the possible association of insertion/deletion (2G/G) polymorphism at nucleotide -1607 of the MMP-1 promoter with the development and progression of renal cancer MATERIALS AND METHODS: In this study, we genotyped 217 individuals, 99 patients with renal cell carcinoma (RCC) and 118 controls without cancer. DNA specimens were extracted from epithelial buccal cells and paraffin-embedded tissue of RCC patients and from epithelial buccal cells and blood cells of healthy controls RESULTS: The difference in frequency of 2G/2G genotype between controls (22.9%) and RCC patients (28.6%) was not statistically significant (p = 0.461). We also did not find correlation between 2G/2G and histological type of RCC. The comparison of genotype distribution and frequency of 2G allele in different populations showed a strong variability of 2G allele frequency among the different ethnic groups. This fact may influence on the collaboration of this 2G allele in RCC or others diseases CONCLUSION: Our data suggest that the matrix metalloproteinase-1 (MMP-1) promoter polymorphism may not play a significant role in renal cell carcinoma patients in Brazil.
ISSN: 1677-5538
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