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Title: Effects of the angiotensin II Ala-scan analogs in erythrocytic cycle of Plasmodium falciparum (in vitro) and Plasmodium gallinaceum (ex vivo)
Authors: Silva, Adriana Farias
Silva, Leandro de Souza
Alves, Flavio Lopes [UNIFESP]
TorossianTorres, Marcelo Der
SaPinheiro, Ana Acacia de
Miranda, Antonio
LaraCapurro, Margareth
Oliveira, Vani Xavier
Universidade Federal do ABC (UFABC)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Ala-scan angiotensin II
Angiotensin II
P. falciparum
P. gallinaceum
Issue Date: 1-Jun-2015
Publisher: Elsevier B.V.
Citation: Experimental Parasitology. San Diego: Academic Press Inc Elsevier Science, v. 153, p. 1-7, 2015.
Abstract: The anti-plasmodium activity of angiotensin II and its analogs have been described in different plasmodium species. Here we synthesized angiotensin II Ala-scan analogs to verify peptide-parasite invasion preservation with residue replacements. the analogs were synthesized by 9-fluorenylmethoxycarbonyl (Fmoc) and tert-butyloxycarbonyl (t-Boc) solid phase methods, purified by liquid chromatography and characterized by mass spectrometry. the results obtained in Plasmodium falciparum assays indicated that all analogs presented some influence in parasite invasion, except [Ala(4)]-Ang II (18% of anti-plasmodium activity) that was not statistically different from control. Although [Ala(8)]-Ang II presented a lower biological activity (20%), it was statistically different from control. the most relevant finding was that [Ala(5)]-Ang II preserved activity (45%) relative to Ang II (47%). in the results of Plasmodium gallinaceum assays all analogs were not statistically different from control, except [Ala(6)]-Ang II, which was able to reduce the parasitemia about 49%. This approach provides insight for understanding the importance of each amino acid on the native Ang II sequence and provides a new direction for the design of potential chemotherapeutic agents without pressor activity. (C) 2015 Elsevier Inc. All rights reserved.
ISSN: 0014-4894
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