Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/39117
Title: Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity
Authors: Netto, Barbara Dal Molin [UNIFESP]
Bettini, Solange Cravo
Clemente, Ana Paula Grotti [UNIFESP]
Carvalho Ferreira, Joana Pereira de [UNIFESP]
Boritza, Katia
Souza, Sandy de Fatima
Von der Heyde, Maria Emilia
Earthman, Carrie P.
Damaso, Ana R. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná (UFPR)
Univ Minnesota Twin Cities
Keywords: Roux-en-Y gastric bypass
Obesity
Inflammation
Hyperleptinemia
Cardiovascular
Issue Date: 1-Jun-2015
Publisher: Springer
Citation: Obesity Surgery. New York: Springer, v. 25, n. 6, p. 1010-1018, 2015.
Abstract: The low-grade inflammatory state in obesity leads to insulin resistance and endothelial dysfunction, which promote cardiovascular diseases in individuals with obesity. the purpose of this study was to evaluate the early effects of weight loss achieved through bariatric surgery on the inflammatory and prothrombotic states. This study also aimed to identify the role of hyperleptinemia on the prothrombotic state.The sample was composed of 41 extremely obese who underwent Roux-en-Y gastric bypass (RYGB). Anthropometric and clinical data, and biochemical markers of inflammation were collected prior to surgery and 6 months post-RYGB.It was found that plasminogen activator inhibitor-1 (PAI-1) concentrations were higher among extremely obese individuals with hyperleptinemia than in those without hyperleptinemia (p < 0.01).In relation to the baseline, post-surgery body mass index (BMI) was reduced by 12.9 kg/m(2), corresponding to 63.50 % of excess weight loss. Additionally, waist circumference was found to decrease significantly from 126.2 to 101.4 cm. Plasma total cholesterol (p < 0.01), LDL cholesterol (p = 0.02), triglycerides (p < 0.01), and glucose (p = 0.01) were also found to decrease. Pro-inflammatory biomarkers were observed to decrease: PAI-1 by 55.9 +/- 6.0 % (p < 0.01), C-reactive protein (CRP) by 18.8 +/- 3.4 % (p < 0.01), intercellular adhesion molecule-1 (ICAM-1) by 89.9 +/- 5.7 % (p < 0.01), leptin by 27.9 +/- 3.2 % (p < 0.01), and resistin by 69.3 +/- 5.8 % (p < 0.01). Additionally, significant decreases of tumor necrosis factor alpha (TNF-alpha) and leptin/adiponectin ratio were observed. Anti-inflammatory cytokines adiponectin and interleukin-10 (IL-10) were significantly increased (170.7 +/- 82.5 %, p < 0.01; 122.7 +/- 55.1 %, p = 0.02). CRP levels were predictive of ICAM-1 (p = 0.04), and changes in leptin concentrations were associated with decreased PAI-1 levels (p = 0.03).We observed that individuals with obesity that have hyperleptinemia have higher circulating PAI-1 levels, which could indicate increased risk for cardiovascular disease. the biomarkers of inflammation and thrombosis measured in this study decreased after RYGB, suggesting that the surgery may be effective in reducing pro-inflammatory and thrombotic risk in individuals with extreme obesity.
URI: http://repositorio.unifesp.br/handle/11600/39117
ISSN: 0960-8923
Other Identifiers: http://dx.doi.org/10.1007/s11695-014-1484-7
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.