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Title: First Proposed Panels on Acute Leukemia for Four-Color Immunophenotyping by Flow Cytometry from the Brazilian Group of Flow Cytometry-GBCFLUX
Authors: Ikoma, Maura R. V.
Sandes, Alex F. [UNIFESP]
Thiago, Leandro S.
Cavalcanti Junior, Geraldo B.
Lorand-Metze, Irene G. H.
Costa, Elaine S.
Pimenta, Glicinia
Santos-Silva, Maria C.
Bacal, Nydia S.
Yamamoto, Mihoko [UNIFESP]
Souto, Elizabeth X.
Hosp Amaral Carvalho
Fleury Grp
Universidade Federal de São Paulo (UNIFESP)
Brazilian Natl Canc Inst INCa
Univ Fed Rio Grande do Norte
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal do Rio de Janeiro (UFRJ)
Lab Diagnost Amer
Universidade Federal de Santa Catarina (UFSC)
Hosp Israelita Albert Einstein
Ctr Hematol
Keywords: flow cytometry
acute leukemia panel
acute lymphoblastic leukemia
acute myeloblastic leukemia
Issue Date: 1-May-2015
Publisher: Wiley-Blackwell
Citation: Cytometry Part B-clinical Cytometry. Hoboken: Wiley-Blackwell, v. 88, n. 3, p. 194-203, 2015.
Abstract: Multiparameter flow cytometry is a highly sensitive, fast, and specific diagnostic technology with a wide range of applicability in hematology. Although well-established eight-color immunophenotyping panels are already available, most Brazilian clinical laboratories are equipped with four-color flow cytometer facilities. Based on this fact, the Brazilian Group of Flow Cytometry (Grupo Brasileiro de Citometria de Fluxo, GBCFLUX) for standardization of clinical flow cytometry has proposed an antibody panel designed to allow precise diagnosis and characterization of acute leukemia (AL) within resource-restricted areas. Morphological analysis of bone marrow smears, together with the screening panel, is mandatory for the primary identification of AL. the disease-oriented panels proposed here are divided into three levels of recommendations (mandatory, recommendable, and optional) in order to provide an accurate final diagnosis, as well as allow some degree of flexibility based on available local resources and patient-specific needs. the proposed panels will be subsequently validated in an interlaboratory study to evaluate its effectiveness on the diagnosis and classification of AL. (Assoc editor comm. 2). (c) 2015 International Clinical Cytometry Society
ISSN: 1552-4949
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