Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/38978
Title: Pinealectomy interferes with the circadian clock genes expression in white adipose tissue
Authors: Mendes de Farias, Talita da Silva
Oliveira, Ariclecio Cunha de
Andreotti, Sandra
Amaral, Fernanda Gaspar do [UNIFESP]
Chimin, Patricia
Alves de Proenca, Andre Ricardo
Leonardo Torres Leal, Francisco
Laurato Sertie, Rogerio Antonio
Campana, Amanda Baron
Lopes, Andressa Bolsoni
Souza, Arnaldo Henrique de
Cipolla-Neto, Jose
Lima, Fabio Bessa
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: adipose tissue
clock genes
melatonin
metabolism
pinealectomy
Issue Date: 1-Apr-2015
Publisher: Wiley-Blackwell
Citation: Journal of Pineal Research. Hoboken: Wiley-Blackwell, v. 58, n. 3, p. 251-261, 2015.
Abstract: Melatonin, the main hormone produced by the pineal gland, is secreted in a circadian manner (24-hr period), and its oscillation influences several circadian biological rhythms, such as the regulation of clock genes expression (chronobiotic effect) and the modulation of several endocrine functions in peripheral tissues. Assuming that the circadian synchronization of clock genes can play a role in the regulation of energy metabolism and it is influenced by melatonin, our study was designed to assess possible alterations as a consequence of melatonin absence on the circadian expression of clock genes in the epididymal adipose tissue of male Wistar rats and the possible metabolic repercussions to this tissue. Our data show that pinealectomy indeed has impacts on molecular events: it abolishes the daily pattern of the expression of Clock, Per2, and Cry1 clock genes and Ppar expression, significantly increases the amplitude of daily expression of Rev-erb, and affects the pattern of and impairs adipokine production, leading to a decrease in leptin levels. However, regarding some metabolic aspects of adipocyte functions, such as its ability to synthesize triacylglycerols from glucose along 24hr, was not compromised by pinealectomy, although the daily profile of the lipogenic enzymes expression (ATP-citrate lyase, malic enzyme, fatty acid synthase, and glucose-6-phosphate dehydrogenase) was abolished in pinealectomized animals.
URI: http://repositorio.unifesp.br/handle/11600/38978
ISSN: 0742-3098
Other Identifiers: http://dx.doi.org/10.1111/jpi.12211
Appears in Collections:Em verificação - Geral

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