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Title: Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing
Authors: Corgosinho, Flavia Campos [UNIFESP]
Ackel-D'Elia, Carolina [UNIFESP]
Tufik, Sergio [UNIFESP]
Damaso, Ana Raimunda [UNIFESP]
Piano, Aline de [UNIFESP]
Sanches, Priscila de Lima [UNIFESP]
Silveira Campos, Raquel Munhoz da [UNIFESP]
Silva, Patricia Leao [UNIFESP]
Carnier, June [UNIFESP]
Tock, Lian
Andersen, Monica Levy [UNIFESP]
Moreira, Gustavo Antonio [UNIFESP]
Pradella-Hallinan, Marcia [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Mello, Marco Tulio de
Universidade Federal de São Paulo (UNIFESP)
Weight Sci
Universidade Federal de Minas Gerais (UFMG)
Issue Date: 1-Apr-2015
Publisher: Mary Ann Liebert, Inc
Citation: Metabolic Syndrome and Related Disorders. New Rochelle: Mary Ann Liebert, Inc, v. 13, n. 3, p. 110-118, 2015.
Abstract: Obesity is considered a chronic subinflammatory disease and is a risk factor for many diseases such as sleep-disordered breathing (SDB). Although the interaction between obesity and sleep has been explored, not much is known about SDB in the adolescent population. Thus, the aims of this study were, first, to verify the effect of 1 year of interdisciplinary therapy on inflammatory markers in SDB and without SDB and, second, to investigate the influence of SDB on the result of the therapy by comparing these groups. A total of 36 obese adolescents were enrolled; however, only 24 completed the therapy (SDB group, n=12; non-SDB obese group, n=12). Sleep, anthropometric, metabolic, and inflammatory profiles were evaluated at baseline and after the treatment. in both groups, the therapy was able to improve all anthropometric variables. Metabolic parameters such as insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI) were significantly improved only in non-SDB group. in both groups, the inflammatory state was significantly improved by the reduction in the leptin/adiponectin ratio. After the intervention, both groups no longer presented the hyperleptinemic state, favoring not only the inflammatory state, but also neuroendocrine regulation. Regarding the sleep parameter, the SDB group improved significantly in all respiratory events, and after therapy only four patients remained with SDB. Furthermore, there was an increase in sleep time. the lifestyle intervention was able to improve anthropometric, metabolic, and inflammatory parameters in both groups; however, the presence of SDB impaired better results. the data supported that the inclusion of SDB in the metabolic syndrome because of the link shown between them.
ISSN: 1540-4196
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